To determine the effectiveness of bacteriostatic normal saline infiltration on the improvement of corticosteroid-induced cutaneous atrophy. Ahmed I. Post-injection involutional lipoatrophy: Ultrastructural evidence for an activated macrophage phenotype and macrophage related involution of adipocytes. Without complete medical history very hard to advise. Didn't find the answer you were looking for? The exact mechanism of action is poorly understood, but studies suggest that corticosteroid crystals persist in the subcutaneous tissue, resulting in fat involution.2 Histopathology typically demonstrates smaller and fewer fat cells, as well as lipophage-like macrophages without evidence of inflammation or necrosis.3,9 Glucocorticoids also reduce the production of type 1 and type 3 collagen.10. Juicygirl, now that it's been a few years, did the dent eventually fill in? I've tried doing manual therapy to it but nothing helps. However, these lesions can be significant, located in cosmetic areas, and problematic for the patient, which are all reasons why acute treatment may be pursued. using the keywords: saline, physiological, hypertonic, isotonic, hypotonic, salt solution, sodium chloride, 0.9% NaCl, solvent, drug delivery, injection mixtures, diluent, sclerosant, intravenous, intralesional, injection, topical, soaks, fomentation, inhalation, alopecia, psoriasis, scars, atopic dermatitis, eczema, bromoderma, iododerma, lipodystrophy, in various combinations with the Boolean operators AND, OR and NOT. While we do connect people with vetted, board-certified doctors, we dont provide medical consultations, diagnosis, or advice. Making a dent with corticosteroid injections for de Quervain's tenosynovitis. Four patients with corticosteroid-induced atrophy of the skin, two caused by acneiform cysts and one from intramuscular steroid injection, were treated with weekly injections of normal saline directly into the atrophic site. Thank you for the response and good advice sadpotatoes. Consultant. The site is secure. Cortisone shots aren't intended for blackheads or whiteheads, the kind of blemishes that go away in a matter of days with topical treatment.

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