transfusions, and iron studies. at the Cleveland Clinic Health System (CCHS) reviewing the use of 2014 Oct;46(10):1983-95. doi: 10.1007/s11255-014-0800-4. A local search option of this data can be found here. Alternative dose: 600 units/kg in once weekly doses (21, 14, and 7 days before surgery) plus a fourth dose on the day of surgery. Both drugs are costly: January 2003 prices posted by Medicare put reimbursement rates at $12.69 per 1000 units of Procrit (translating to about $534.32 for the Average Wholesale Price [AWP] for a once-a-week dose of 40,000 units) and $23.69 per 5 micrograms of Aranesp (about $994.98 for the AWP for a 3 mcg/kg dose every other week). this interchange program should be directed to the CCF Department %PDF-1.5 of the molecule is a more important determinant of potency and receptor Select one or more newsletters to continue. *For pediatric patients receiving a weekly epoetin alfa dose of < 1,500 Units/week, the available data are insufficient to determine an Aranesp conversion dose. endstream endobj 336 0 obj <>stream . Retacrit (epoetin alfa-epbx) Biosimilar Formulary Preferred Use Retacrit group. Severe chronic neutropenia: Congenital: 6 mcg/kg twice daily Idiopathic/cyclic: 5 mcg/kg/day, https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=9222, Supplied: Injection, solution [preservative free]: 300 mcg/mL (1 mL, 1.6 mL) [vial; contains sodium 0.035 mg/mL and sorbitol], Injection, solution [preservative free]: 600 mcg/mL (0.5 mL, 0.8 mL) [prefilled Singleject syringe; contains sodium 0.035 mg/mL and sorbitol], Drug UPDATES: ZARXIO - filgrastim-sndz injection [Drug information / PDF] Click link for the latest monographDosing: Click (+) next to Dosage and Administration section (drug info link). Decreases in dose can occur more frequently. Retacrit has not been shown to be interchangeable with U.S.-licensed Epogen/Procrit. RETACRIT from multiple-dose vials contains benzyl alcohol and is contraindicated in: For additional details on storage and handling. Please enable it to take advantage of the complete set of features! See full prescribing information for RETACRIT. The While a discounted alternative to Epogen and Procrit is welcome, there is a catch. For patients who do not respond adequately, if the hemoglobin has not increased by more than 1 g/dL after 4 weeks of therapy, increase the dose by 25%. PDF Policy Title: Erythropoiesis stimulating agents: Retacrit (epoetin alfa 500 mcg every 3 weeks subcutaneously until completion of a chemotherapy course. k22atr !h~h[={;X)Sr;:2{+S&x~tlgth6_'N'F?%2 @obXCC Neumega is not indicated following myeloablative chemotherapy (see package insert for WARNINGS, Increased Toxicity Following Myeloablative Therapy). Endogenous G-CSF is a lineage specific colony-stimulating factor which is produced by monocytes fibroblasts, and endothelial cells. of endogenous erythropoietin may be impaired in patients receiving Adverse effects on PFS and/or OS were observed in studies of patients receiving chemotherapy for breast cancer, lymphoid malignancy, and cervical cancer; in patients with advanced head and neck cancer receiving radiation therapy; and in patients with non-small cell lung cancer or various malignancies who were not receiving chemotherapy or radiotherapy, RETACRIT is contraindicated in patients with uncontrolled hypertension. Dosage form: injection, solution %%EOF Before prescribing RETACRIT single-dose vials to a patient with PKU, consider the combined daily amount of phenylalanine from all sources, including RETACRIT, Patients may require adjustments in their dialysis prescriptions after initiation of RETACRIT. Would you like email updates of new search results? Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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