If a decision is made to prescribe XANAX XR concomitantly with opioids, prescribe the lowest effective dosages and minimum durations of concomitant use, and follow patients closely for signs and symptoms of respiratory depression and sedation. Because of its CNS depressant effects, patients receiving XANAX XR should be cautioned against engaging in hazardous occupations or activities requiring complete mental alertness such as operating machinery or driving a motor vehicle. (, Neonatal Sedation and Withdrawal Syndrome (NOWS): Use of XANAX XR during pregnancy can result in neonatal sedation and neonatal withdrawal syndrome. 2mg Xanax What are the possible side effects of XANAX XR? Flumazenil may be useful in situations when an overdose with a benzodiazepine is known or suspected. Alprazolam was negative in the in vitro Ames bacterial reverse mutation assay and DNA Damage/Alkaline Elution Assay and in vivo rat micronucleus genetic toxicology assays. The initial step in alprazolam metabolism is hydroxylation catalyzed by cytochrome P450 3A (CYP3A). i am honestly leaving my review its good experience with this website. Advise mothers using XANAX XR to monitor neonates for signs of sedation, respiratory depression, withdrawal symptoms, and feeding problems. (6.1). Alprazolam exerts its effect for the treatment of panic disorder through binding to the benzodiazepine site of gamma-aminobutyric acid-A (GABAA) receptors in the brain and enhances GABA-mediated synaptic inhibition. Pfizer Xanax Packaging & Bottle Protect from light. Benzodiazepines cross the placenta and may produce respiratory depression and sedation in neonates. The mean T1/2 of alprazolam was 21.8 hours (range: 9.9 to 40.4 hours) in a group of obese subjects. Subsequently decrease the dosage more slowly [see Warnings and Precautions (5.3), Drug Abuse and Dependence (9.3)]. XANAX XR contains alprazolam, which is a Schedule IV controlled substance. You should not breastfeed while taking XANAX XR. Ava is a digital health aid for womens health including cycle tracking, fertility, and pregnancy. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. General information about the safe and effective use of XANAX XR. Monitor neonates exposed to benzodiazepines during pregnancy and labor for signs of sedation, respiratory depression, withdrawal, and feeding problems and manage accordingly [see Warnings and Precautions (5.4)].

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